abstract：:c-Fos protein-like immunoreactivity (IR) was investigated in the rat brain following an application of weak anodal direct current to the surface of the unilateral sensorimotor cortex in an attempt to elucidate the cellular and molecular bases of central plasticity. Anodal polarization resulted in a massive increase in...

journal_title：Experimental neurology

authors： Islam N,Moriwaki A,Hattori Y,Hayashi Y,Lu YF,Hori Y

更新日期：1995-05-01 00:00:00

abstract：:Substantial residual neurological function may persist after spinal cord injury (SCI) with survival of as few as 5-10% of the original number of axons. A detailed understanding of the relationships among the severity of injury, the number and origin of surviving axons at the injury site, and the extent of neurological...

journal_title：Experimental neurology

authors： Fehlings MG,Tator CH

更新日期：1995-04-01 00:00:00

abstract：:Pretreatment with the synthetic glucocorticoid dexamethasone prevents hypoxic-ischemic brain damage in 7-day-old neonatal rats. We presently characterize the response further by examining the effect of varying the age, the glucocorticoid, and the time of injection and by examining whether fasting can influence the res...

journal_title：Experimental neurology

authors： Tuor UI,Chumas PD,Del Bigio MR

更新日期：1995-03-01 00:00:00

abstract：:Ethanol withdrawal (ETX) in ethanol-dependent rats results in susceptibility to seizures, including generalized tonic-clonic audiogenic seizures (AGS). The inferior colliculus (IC) is strongly implicated in AGS initiation during ETX, but IC neuronal mechanisms subserving AGS are unclear. The present study examined IC ...

journal_title：Experimental neurology

authors： Faingold CL,Riaz A

更新日期：1995-03-01 00:00:00

abstract：:The beta-Amyloid peptide (A beta) is hypothesized to mediate the neurodegeneration seen in Alzheimer's disease. Recently, we proposed a new hypothesis to explain the toxicity of A beta based on the free-radical generating capacity of A beta. We have recently demonstrated using electron paramagnetic resonance (EPR) spe...

journal_title：Experimental neurology

authors： Harris ME,Hensley K,Butterfield DA,Leedle RA,Carney JM

更新日期：1995-02-01 00:00:00

abstract：:Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...

journal_title：Experimental neurology

authors： Martin D,Near SL,Bendele A,Russell DA

更新日期：1995-02-01 00:00:00

abstract：:the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...

journal_title：Experimental neurology

authors： Giusti P,Gusella M,Lipartiti M,Milani D,Zhu W,Vicini S,Manev H

更新日期：1995-01-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

journal_title：Experimental neurology

authors： Kato AC,Lindsay RM

更新日期：1994-12-01 00:00:00

abstract：:Diffuse and neuritic plaques are sites of accumulation of beta-amyloid peptides (A beta) in the brains of Alzheimer's disease (AD) patients. Although amyloid fibrils are formed from A beta, the contribution of other plaque-associated proteins and peptides to the pathogenesis of AD amyloidosis is unknown. To pursue thi...

journal_title：Experimental neurology

authors： Schmidt ML,DiDario AG,Otvos L Jr,Hoshi N,Kant JA,Lee VM,Trojanowski JQ

更新日期：1994-12-01 00:00:00

abstract：:Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined...

journal_title：Experimental neurology

authors： Sivron T,Schwartz M

更新日期：1994-12-01 00:00:00

abstract：:Following cholinergic denervation of the hippocampal formation, peripheral sympathetic fibers from the superior cervical ganglion (SCG) sprout into hippocampal tissue. The molecular mechanism controlling this process is unknown, although a role by trophic factors seems likely. In the present study, neonatal SCG were u...

journal_title：Experimental neurology

authors： Conner JM,Varon S

更新日期：1994-11-01 00:00:00

abstract：:c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-...

journal_title：Experimental neurology

authors： Sugimoto T,Hara T,Shirai H,Abe T,Ichikawa H,Sato T

更新日期：1994-10-01 00:00:00

abstract：:Intracerebral transplants of ventral mesencephalic (VM) tissue have been well characterized. VM grafts contain numerous tyrosine hydroxylase immunoreactive neurons which send axons into the host brain. Transplanted neurons in VM grafts develop normally in that they contain tyrosine hydroxylase and GAP43. An overlooked...

journal_title：Experimental neurology

authors： Mahalik TJ,Hahn WE,Clayton GH,Owens GP

更新日期：1994-09-01 00:00:00

abstract：:It has been suggested that the increased transient expression of immediate-early gene transcription factors seen in nerve cells following an afterdischarge may initiate longer lasting or permanent changes in gene expression which underly the development of kindling. Since the development of kindling is sensitive to ph...

journal_title：Experimental neurology

authors： Hughes P,Singleton K,Dragunow M

更新日期：1994-08-01 00:00:00

abstract：:Trophic factors are expressed by neurons throughout several areas of the CNS. We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in doub...

journal_title：Experimental neurology

authors： Humpel C,Giacobini MM,Wetmore C,Olson L

更新日期：1994-06-01 00:00:00

abstract：:We have previously found that fetal cortex taken from 16- to 18-day-old donors survives grafting to the infarcted cortex 5-7 days after middle cerebral artery occlusion. The present study was undertaken to examine the effect on graft survival of varying the age of the fetal donor tissue and the time between vessel occ...

journal_title：Experimental neurology

authors： Grabowski M,Johansson BB,Brundin P

更新日期：1994-05-01 00:00:00

abstract：:The present study demonstrates that the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes significantly greater reductions in striatal dopamine levels in C57/bl mice than in CD-1 mice, thus confirming a greater sensitivity of the C57/bl mice to MPTP. To determine the possible reasons for this diffe...

journal_title：Experimental neurology

authors： Muthane U,Ramsay KA,Jiang H,Jackson-Lewis V,Donaldson D,Fernando S,Ferreira M,Przedborski S

更新日期：1994-04-01 00:00:00

abstract：:In seven families from a Siberian founder population with autosomal dominant spinocerebellar ataxia (SCA) genetic analysis of the polymorphisms flanking the SCA1 locus on chromosome 6p showed allelic association with disease inheritance. While the association was absolute in the case of microsatellite D6S274, an allel...

journal_title：Experimental neurology

authors： Lunkes A,Goldfarb LG,Platonov FA,Alexeev VP,Duenas-Barajas E,Gajdusek DC,Auburger G

更新日期：1994-04-01 00:00:00

abstract：:Quisqualate (Quis) and other excitotoxins such as ibotenate and N-methyl aspartate, have been used to destroy neurons in the area of the nucleus basalis magnocellularis (NBM) in order to study the relationship between loss of cholinergic neurons in the basal forebrain and various behavioral deficits, including learnin...

journal_title：Experimental neurology

authors： Wozniak DF,Huss J,Olney JW

更新日期：1994-03-01 00:00:00

abstract：:Many reports indicate that GM1 ganglioside is effective in reducing CNS ischemic injury in animal models. These models employ invasive surgery to induce ischemic damage in otherwise healthy animals. The purpose of this study was to determine if the beneficial effects of GM1 could be generalized to Spontaneously Hypert...

journal_title：Experimental neurology

authors： Hernandez NE,MacDonall JS,Stier CT Jr,Belmonte A,Fernandez R,Karpiak SE

更新日期：1994-03-01 00:00:00

abstract：:Adenoviral-mediated gene transfer to the caudate nucleus of Macaca mulatta was accomplished using stereotactic injection of two distinct recombinant Ad5 vectors containing the gene for Escherichia coli beta-galactosidase and the cDNA for rat hypoxanthine-guanine phosphoribosylphosphotransferase (HPRT), respectively. M...

journal_title：Experimental neurology

authors： Davidson BL,Doran SE,Shewach DS,Latta JM,Hartman JW,Roessler BJ

更新日期：1994-02-01 00:00:00

abstract：:In what ways do passive touch and active touch require particular properties of cortical physiology? Because it is not easy to make predictions "bottom up" from neurophysiology and anatomy to behavior, there have been surprises in studying behavioral deficits following selective ablations of SI versus SII. For example...

journal_title：Experimental neurology

authors： Glassman RB

更新日期：1994-01-01 00:00:00

abstract：:The present study evaluates the temporal relationships between increases in glial fibrillary acidic protein (GFAP) mRNA, GFA protein levels, and GFAP immunostaining in the hippocampus of adult rats following unilateral lesions of the entorhinal cortex (EC). GFAP mRNA levels were assessed at 12 h, 1, 2, 4, 6, 8, 10, 12...

journal_title：Experimental neurology

authors： Steward O,Kelley MS,Torre ER

更新日期：1993-12-01 00:00:00

abstract：:As early as 1928, Cajal suggested that plaques contain a trophic substance which attracts neurites. Recently, basic fibroblast growth factor (bFGF) levels were shown to be elevated in Alzheimer's disease (AD) and localized to plaques and neurofibrillary tangles. We sought to clarify the subtype of plaques which contai...

journal_title：Experimental neurology

authors： Cummings BJ,Su JH,Cotman CW

更新日期：1993-12-01 00:00:00

abstract：:Subcortical deafferentation of the rat hippocampus has been suggested to offer a model for developing limbic epilepsy. In the present study, the long-term effect of fimbria-fornix lesioning on the density and distribution of hippocampal N-methyl-D-aspartate (NMDA)-sensitive L-[3H]glutamate binding was studied using qu...

journal_title：Experimental neurology

authors： Lahtinen H,Korhonen E,Castrén E,Miettinen R,Ylinen A,Riekkinen PJ Sr

更新日期：1993-06-01 00:00:00

abstract：:Both fresh and cryopreserved-thawed human fetal ventral mesencephalon have been used for preclinical research and implantation into the brains of patients with Parkinson's disease. Further characterization and an evaluation of the effects of cryopreservation on immunocytochemical and neurochemical markers of monoamine...

journal_title：Experimental neurology

authors： Kontur PJ,Leranth C,Redmond DE Jr,Roth RH,Robbins RJ

更新日期：1993-06-01 00:00:00

abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

journal_title：Experimental neurology

authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

更新日期：1993-05-01 00:00:00

abstract：:Recent studies have implicated nitric oxide (NO) in several mechanisms related to neuronal degeneration and synaptic plasticity. In the present study, two models of traumatic neuronal injury were used to examine the expression of NOS following neuronal injury and its relationship to axonal sprouting and neuronal degen...

journal_title：Experimental neurology

authors： Wu W

更新日期：1993-04-01 00:00:00

abstract：:It is controversial whether levodopa (L-DOPA) therapy in the early stages of Parkinson's disease (PD) predisposes to later complications. Partial lesions of the substantia nigra (SN) in rat provide a model of the early stages of PD. We have investigated the potential effects of L-DOPA in early PD by analyzing its infl...

journal_title：Experimental neurology

authors： Cole DG,Growdon JH,DiFiglia M

更新日期：1993-04-01 00:00:00

abstract：:The aim of this study was to characterize the microglial and astroglial reactions to degeneration of (a) hippocampal CA1 pyramidal cells and dentate hilar neurons induced by cerebral ischemia and (b) CA3 pyramidal cells and dentate hilar neurons induced by intraventricular injections of kainic acid (KA). The microglia...

journal_title：Experimental neurology

authors： Jørgensen MB,Finsen BR,Jensen MB,Castellano B,Diemer NH,Zimmer J

更新日期：1993-03-01 00:00:00

abstract：:There is compelling evidence that excessive exposure to manganese (Mn) produces neurotoxicity, especially in the basal ganglia, resulting in a dystonic Parkinsonian disorder. Several experimental or clinical observations suggest that Mn neurotoxicity could involve impairment of energy metabolism. We examined the neuro...

journal_title：Experimental neurology

authors： Brouillet EP,Shinobu L,McGarvey U,Hochberg F,Beal MF

更新日期：1993-03-01 00:00:00

abstract：:Multiple cellular and molecular interactions are required for the differentiation and development of central neurons. For example, neural activity may modulate trophic function. In the developing cerebellum, establishment of functional excitatory synaptic connections coincides with the expression of NGF and its recept...

journal_title：Experimental neurology

authors： Cohen-Cory S,Elliott RC,Dreyfus CF,Black IB

更新日期：1993-02-01 00:00:00

abstract：:Excitant amino acids are implicated in audiogenic seizure (AGS) susceptibility in the genetically epilepsy-prone rat (GEPR). In the present study systemic administration of NMDA receptor antagonists significantly decreased AGS severity in the GEPR. Systemic administration of the competitive NMDA antagonists 3-((+-)-2-...

journal_title：Experimental neurology

authors： Faingold CL,Randall ME,Naritoku DK,Boersma Anderson CA

更新日期：1993-02-01 00:00:00

abstract：:Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...

journal_title：Experimental neurology

authors： Hagg T,Varon S

更新日期：1993-01-01 00:00:00

abstract：:A 168-nucleotide exon, found in alternatively spliced amyloid precursor protein (APP) mRNAs, encodes a Kunitz protease inhibitor (KPI) domain. Kainic acid (ip) caused a selective increase of KPI mRNA in rat hippocampus. By in situ hybridization, KPI mRNA was induced in the neuronal layers of the hippocampus 11-12 h af...

journal_title：Experimental neurology

authors： Willoughby DA,Johnson SA,Pasinetti GM,Tocco G,Najm I,Baudry M,Finch CE

更新日期：1992-12-01 00:00:00

abstract：:As part of a wider investigation on brain structure and function in young rats with inherited hydrocephalus, this study was undertaken to develop a technique to monitor, and quantify, progressive changes in ventricle and cortical dimensions in hydrocephalic rats in vivo. Magnetic resonance images were obtained with a ...

journal_title：Experimental neurology

authors： Harris NG,Jones HC,Williams SC

更新日期：1992-10-01 00:00:00

abstract：:Neuronal populations projecting to a common target may compete for neurotrophic substances. To determine if competition impairs target reinnervation, we examined the effect of capsaicin-induced sensory denervation on sympathetic nerve ingrowth to the sympathectomized rat superior tarsal smooth muscle. In tarsal muscle...

journal_title：Experimental neurology

authors： Fike EA 4th,Simons E,Boswell C,Smith PG

更新日期：1992-10-01 00:00:00

abstract：:The blood-brain barrier function and the vasomotor response in rat microcirculation was studied using a closed cranial window technique and an intravital fluorescence microscope with an attempt to reduce both the light intensity and the amount of 2% Na(+)-fluorescein to as little as possible. The light intensities in ...

journal_title：Experimental neurology

authors： Kawamura S,Yasui N

更新日期：1992-09-01 00:00:00

abstract：:Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cue...

journal_title：Experimental neurology

authors： Liesi P

更新日期：1992-08-01 00:00:00

abstract：:A number of neuron-supporting functions have been ascribed to astrocytes. In this study we found that a proliferation of Purkinje cell dendritic spines, a target site for presynaptic axon terminals, was induced in cytosine arabinoside-treated cerebellar cultures by exposure to astrocyte-conditioned medium. This result...

journal_title：Experimental neurology

authors： Seil FJ,Eckenstein FP,Reier PJ

更新日期：1992-07-01 00:00:00